Product Description
Function
Pharmacological Research
(1) Hypolipidemic effect: turmeric alcohol or ether extract, curcumin and volatile oil by gavage have significant hypolipidemic effect on total plasma cholesterol and B-lipoprotein in rats and rabbits with experimental hyperlipidemia, and can lower hepatic cholesterol and correct the imbalance of a- and B-lipoprotein ratio, but have no effect on endogenous cholesterol; the effect on lowering plasma triglycerides is more significant, and can reduce plasma triglycerides to normal levels The effect on lowering plasma triglycerides was more significant, lowering plasma triglycerides to below normal levels.
High sucrose diet can cause hyperlipidemia in rats, and curcumin can counteract this hyperlipidemia.
Gavage of curcumin reduced liver weight, decreased liver triglycerides, free fatty acids, phospholipids and serum total triglycerides, VLDL+LDL triglycerides, HDL triglycerides, VLDL+LDL cholesterol and free fatty acids in blood, and also increased serum total and HDL cholesterol levels.
Using liver homogenate in vitro holding method and 14C-acetic acid as substrate test, the preliminary results showed that curcumin can inhibit the synthesis of fatty acids.
(2) Antitumor effect: Tissue culture and in vivo experiments with murine Dalton's lymphatic ascites tumor cells showed that curcumin alcohol extract could inhibit the growth of cancer cells. It can inhibit the growth of Chinese hamster ovary cells at 0.4mg/ml, and has cytotoxic effect on lymphocytes and Dalton's lymphocytes, and can reduce the growth of animal tumors, and its active ingredient is mainly curcumin.
7,12-Dimethylbenzanthracene induced papillary carcinoma in mice promoted by croton oil, and curcumin significantly reduced the chance of papillary carcinoma production in this case, and also inhibited tumor formation induced by 2O-methylchloroanthracene.
Curcumin also reduced the possibility of mutagenic carcinogenesis. Curcumin also inhibits the carcinogenic effect of TPA (12-O-Tetradecanoylphorbol-13-acetate). When 10 μmol/L curcumin was applied topically, the inhibition of guanylate decarboxylase activity induced by 5 nmol/L TPA reached 91%; 10 μmol/L curcumin applied topically with 2 nmol/L TPA- up inhibited TPA-initiated 3H-thymidine chimerism into epidermal DNA by 49%, and the inhibition rate was concentration-dependent. Therefore, curcumin may act as an anti-cancer agent.
(3) Anti-inflammatory effect: Curcumin counteracted the swelling of rat toes induced by keratin gum in a dose-dependent manner in the range of 30 mg/kg, whereas this anti-inflammatory effect was inhibited at a dose of 60 mg/kg. Curcumin sodium reversibly inhibited nicotine, acetylcholine, 5-hydroxytryptamine, barium chloride and histamine-induced ileal contraction in isolated guinea pigs, similar to non-steroidal anti-inflammatory drugs.
(4) Anti-pathogenic microbial effect: In vitro test, curcumin has inhibitory effect on Micrococuspyogenesvar. Aureus at one percent concentration. The volatile oil has a strong antifungal effect. Turmeric prolongs the survival time of virus-inoculated mice.
(5) Effects on cardiovascular system: Curcumin intravenously has no significant effect on blood pressure, nor on blood pressure induced by adrenaline, histamine and acetylcholine. Gavage with curcumin can counteract S-T and T-wave changes in the electrocardiogram of rats caused by intravenous injection of posterior pituitary hormone, and gavage can also increase the nutritional blood flow in the myocardium of mice.
Curcumin had a significant effect on platelet aggregation and blood viscosity. In vitro experiment of curcumin at a concentration of 1×10(-4) mol/L in normal human significantly inhibited platelet aggregation with an inhibition rate of 35.4% (P<0.01). After 5 days of gavage (at doses of 20, 40, 60 and 80 mg/(kg.day)), platelet aggregation was reduced and plasma viscosity and whole blood viscosity were decreased compared with the control group. The inhibition of platelet aggregation was the strongest in the 40 mg/(kg.day) group, with an inhibition rate of 34.6% (P<0.05). The inhibitory effect was not progressively enhanced by continuing to increase the dose. The reduction of whole blood and plasma viscosity was significant at low shear rate (37.5 s-1), while no significant difference was observed at high shear rate (150 s-1).
(6) Choleretic effect: turmeric extract, curcumin, volatile oil, curcuminoids, as well as gingerene, lobster and sesquiterpene alcohol, etc., are choleretic, can increase the production and secretion of bile, and can promote the contraction of the gallbladder, and the effect of curcumin is the strongest.
(7) Effect on termination of pregnancy: Turmeric was made into 100% (raw 1g/ml) and 200% aqueous decoction. Mice were injected intraperitoneally or subcutaneously with 10 g/kg of turmeric aqueous decoction once daily for 2 days in early (6-7 days), middle (10-14 days) and late (16-18 days) stages of pregnancy. In early and mid-term pregnant mice, vaginal bleeding was seen in the early morning of the next day after 1 administration, and necrotic and degenerated embryos were seen in the uterus by autopsy. In late pregnant mice, most of the mice were delivered within 24 hours after 1 administration of the drug. It was shown that intraperitoneal or subcutaneous administration of the drug had significant effects on all stages of pregnancy in mice (oral administration of 50 g/kg was not effective), and the termination rate of pregnancy was 90-100%, while the embryos in the control group developed normally.
In rabbits, 8 g/kg of turmeric aqueous decoction was injected intraperitoneally or subcutaneously once daily for 2-3 days at early (8-10 days), middle (13-15 days) and late (23-25 days) stages of pregnancy, and all 8 early pregnant rabbits and 4 middle pregnant rabbits terminated their pregnancies and all 4 late pregnant rabbits aborted. In the control group, all 6 rabbits had normal pregnancies.
The estrogenic and anti-estrogenic activities of turmeric were determined by the uterine weight gain method in immature mice, which showed that turmeric aqueous decoction 10 g/kg was not estrogenic or anti-estrogenic when injected intraperitoneally or subcutaneously.
The effect of turmeric 10g/kg on termination of early pregnancy in animals was antagonized by progesterone (1mg/mouse), and turmeric 10g/kg also significantly inhibited the growth of traumatic uterine ecdysteroids in pseudopregnant mice, so it is speculated that the mechanism of the early abortion effect caused by turmeric in animals may be due to its anti-progestogenic activity and uterine contraction.
Turmeric powder was sequentially extracted with petroleum ether, 95% ethanol and water by continuous gavage on days l-7 of pregnancy, and the termination rates of pregnancy in female rats were 100, 70 and 100% at a dose of 100 mg/kg of the three extracts, respectively. No malformation was observed in the born pups. All the above three extracts had no effect on copper sulfate-induced ovulation in rabbits.
(8) Antioxidant effect: Homogenates were made from the brain, heart, liver, kidney and spleen of NIH mice at certain concentrations, and the unsaturated fatty acids were oxidized to lipid peroxide, which was quickly converted to malondialdehyde, and the reaction of malondialdehyde with thiobarbituric acid under heating conditions to form a red compound was tested. The concentrations of homogenate in each organ were 3.39% in brain, 1.16% in heart, 3.97% in liver (1), 3.94% in liver (2), 2.08% in kidney and 1.67% in spleen; the doses of curcumin (mg/100ml) were 0.31-0.123 in brain, 20.4-0.8 in heart, 20.4-0.8 in liver (1), 0.8-0.128 in liver (2), 20.4-0.8 in kidney and 20.4-0.8 in spleen. It was also reported that curcumin and 4-Hydroxycinnamoyl (geruloyl) methane, bis (4-Hydroxycinnamoyl)methane have antioxidant effects, with curcumin being the best, with a 50% inhibition concentration of 1.83×10(-2)% (thiobarbitone value) and 1.15×10(-2)% (peroxide value) on the air oxidation of linoleic acid, both higher than that of vitamin E.
(9) Photoeffective effects: Curcumin is normally weakly bactericidal, but when given to light irradiation, microgram amounts of curcumin showed a strong phototoxic response. Gram-negative bacteria are more resistant to curcumin phototoxicity than Gram-positive. This phototoxicity of curcumin can only be produced in the presence of oxygen. Thus curcumin may be used as a photosensitizing agent in the phototherapy of psoriasis, cancer, bacterial and viral diseases. Curcumin also acts as a stabilizer for drugs that are susceptible to photolysis. For example, it has a particularly strong photostabilizing effect on nifedipine, which prolongs its half-life by six times and can enhance its therapeutic effect.
(10) Other effects: curcumin can inhibit the biosynthesis of PGS. Turmeric can also kill flies. Chloroform and ether extracts of turmeric inhibit S. fungus and S. petechiae in vitro.Turmeronol A and B inhibit soybean lipoxygenase with IC50 of 16 and 19 μmol/L, respectively.These two compounds prevent auto-oxidation of linoleic acid at -200 ppm concentration.
Certifications
Audited Supplier 
){kind=link}
){kind=link}